Octodon degus: A Model for the Cognitive Impairment Associated with Alzheimer's Disease
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Título Artículo / Títol Article: Octodon Degus: a Model for the Cognitive Impairment Associated with Alzheimer's Disease Octodon Degus: a Model for the Cognitive Impairment Associated with Alzheimer's Disease
Octodon degus (O. degus) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O. degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concerned with neurodegenerative diseases in which risk is associated with ageing. O...
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The most popular animal models of Alzheimer’s disease (AD) are transgenic mice expressing human genes with known mutations which do not represent the most abundant sporadic form of the disease. An increasing number of genetic, vascular and psychosocial data strongly support that the Octodon degus, a moderate-sized and diurnal precocial rodent, provides a naturalistic model for the study of the ...
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To examine if a feature of episodic-like memory reported in rats is shared with other species, we investigated whether degus would form an integrated memory of object (what), place (where), and context (which). We used two E-shaped mazes with different contexts regarding the wall and the floor. Degus were entered into the middle arm and first explored the maze with two trial-unique objects plac...
متن کاملOctodon Degus: A Strong Attractor for Alzheimer Research
The most popular animal models of Alzheimer's disease (AD) are transgenic mice expressing human genes with known mutations which do not represent the most abundant sporadic form of the disease. An increasing number of genetic, vascular and psychosocial data strongly support that the Octodon degus, a moderate-sized and diurnal precocial rodent, provides a naturalistic model for the study of the ...
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ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2013
ISSN: 1755-5930
DOI: 10.1111/cns.12125